Leptin vs fructose

To keep from getting hungry, leptin comes into play. 


Foods that block leptin signalling include sugars, HFCS, and fruits ok.
Fructose directly causes insulin resistance and reduction in leptin signaling (1 l or 2? i do not know). Glucose cause reduced signaling indirectly through higher insulin. MSG, alcohol, artificial sweeteners, including stevia, all directly block leptin.


So any weight loss program should avoid all leptin signal blocking foods, even trace amounts. That means no fruits. None. Noda. Different people have different levels of leptin blocking from fructose, ah, the old dose dependent variation, probably normal distribution, and as I have always been fat, I will be on the low dose tail.


When I was losing, I was not eating fruit. That is the first thing I took back to stabilize my weight, and have been gaining ever since, and hungry. Time to test this theory. No fruit for a while.   

Even the amount of fructose in fruit causes leptin resistance/leptin blocking/hunger for some of us. Anyone trying to lose weight should not take in any fructose. After you are happy with your weight, feel free to add fruit. See Lustig’s work.

Calories is only one gross issue; appetite control is the other. It is only my opinion that anyone who is trying to loss weight should do all practical to reduce appetite. That includes no fructose, but what do I know.

Here is what someone else suggests.


To control your appetite and hunger you can keep keep your leptin levels high by doing the following.

• Avoid high fructose corn syrup and too much sugar. High fructose corn syrup blocks leptin from letting your brain know that you are done eating. The brain does not recognize fructose as a real food and it makes you keep eating. Sugars make your brain less sensitive to leptin.
• Eat your healthy fats, monounsaturated fats and polyunsaturated fats. The healthy fats help boost your leptin levels, so they are more satisfying than saturated fats. Both are also great for you heart and arteries.
• Take zinc. Zinc increases your leptin levels. You can buy zinc in 15mg packets or get it from your multivitamin, which usually contains 12mg 
• Stop crash diets. When you lose a lot of weight quickly from serious calorie restriction, your leptin levels plummet. So you get hungrier, your thyroid decreases output and your metabolic rate drops.
• Eat ONE large meal per week.Your body then senses the rush of fuel and boosts leptin levels, increasing your metablism and priming your body for fat loss. 
• Sleep well. Research has found that shorter sleep periods (6 hours or less) lowers leptin levels, cause an increase in appetite and make people crave carbs and other fattening foods. 

leptin

Debra's at http://justmaintaining.com comment to Sharma got me thinking:

Debra's recent comment on Dr. Sharma (http://www.drsharma.ca/the-uncertainty-of-behavioural-obesity-management.html)  states  "Perhaps, but here’s the problem: You can address the “whys” to attain a weight loss, but once a body is weight reduced it is barraged by dozens of new, different “whys” that challenge it in maintaining this loss. You have written on many of them: In weight-reduced people, leptin is chronically suppressed, ghrelin is chronically elevated, other hormones, gut peptides and natural chemicals are out of whack, and metabolic function is about 20% slower than a person whose nautral weight is the same as the reduced person’s current weight. Dieters are unprepared for these issues, and their doctors are ignorant of them. So, patients may resolve the problems causing, say, “emotional eating” (as an example), lose weight, feel completely in control of their situation, but then, shortly, regain their weight nevertheless."

I question -leptin is chronically suppressed. According to Dr. Lustic, leptin is not suppressed, but rather the signal is blocked by insulin hogging the shared receptors. That is why fasting insulin is such an issue.  It does not matter, we still need to learn to live with it.

I did not know "ghrelin is chronically elevated".

K. Hall and C. Chow graph the animal "metabolic function is about 20% slower than a person whose natural weight" and show much more than 20%, much like 0 to 50%, depending on the O2 / Co2  ratio, in effect the carbohydrate/fat burn ratio. Oh - the wonders of partial differential equations, and a engineering degree to help me understand them.  See, all that Calculus was not a total waste.  I, we, the ex-obese are better off burning fat.

We go through a cycle; appetite, eating, satiation, life which stimulates appetite, and back to appetite. Most of my relief has come through reduction of those things that stimulate appetite. EG no grains, sugar, manufactured oils, insulin stimulating foods, and give leptin a chance. There should be a song there somewhere. All those why's of eating just need to be ditched.

Also, I just finished Dr. Sharma book. A good read, and a few new things in the puzzle that is obesity recovery. Fasting Insulin, any non-diabetic one ever been tested?  No absolutes, I do not think so. I never was tempted to eat poisons, therefore absolutes work. No sugar. No grain. No manufactured oils.



Did you all see McLeans Sept 26 issue, page 14. Dr Davis hit the big time in Canada.

Lustig, leptin

Dr. R, Lustig said 

Childhood obesity has become epidemic over the past 30 years. The First Law of Thermodynamics is routinely interpreted to imply that weight gain is secondary to increased caloric intake and/or decreased energy expenditure, two behaviors that have been documented during this interval; nonetheless, lifestyle interventions are notoriously ineffective at promoting weight loss.

Obesity is characterized by hyperinsulinemia. Although hyperinsulinemia is usually thought to be secondary to obesity, it can instead be primary, due to autonomic dysfunction. Obesity is also a state of leptin resistance, in which defective leptin signal transduction promotes excess energy intake, to maintain normal energy expenditure. Insulin and leptin share a common central signaling pathway, and it seems that insulin functions as an endogenous leptin antagonist.

Suppressing insulin ameliorates leptin resistance, with ensuing reduction of caloric intake, increased spontaneous activity, and improved quality of life. Hyperinsulinemia also interferes with dopamine clearance in the ventral tegmental area and nucleus accumbens, promoting increased food reward.

Accordingly, the First Law of Thermodynamics can be reinterpreted, such that the behaviors of increased caloric intake and decreased energy expenditure are secondary to obligate weight gain. This weight gain is driven by the hyperinsulinemic state, through three mechanisms: energy partitioning into adipose tissue; interference with leptin signal transduction; and interference with extinction of the hedonic response to
food.

The Rosedale diet by Dr. Ron Rosedale explores dietary solutions for correcting leptin imbalances.
The Fat Resistant Diet by Leo Galland is anti-inflammatory diet that also addresses leptin.
Mastering Leptin by Byron Richards (2004) also addresses leptin imbalances.

Also, elsewhere, it is suggested that Vitamin C is a precursor for leptin, and a 500 UI dose of sodium ascorbate after each meal will fix you up. It is also suggested that sodium ascorbate is a precursor to cortisol and will effect your blood glucose measurements. It is not clear if it effects the blood glucose or just the measurement. Other forms of Vit C have reduced  effect...OK.